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The Role of SERMs in Managing the Most Bothersome Symptoms of Vulvovaginal Atrophy: Dyspareunia and Dryness

The Role of SERMs in Managing the Most Bothersome Symptoms of Vulvovaginal Atrophy:  Dyspareunia and Dryness

SERMs are a versatile group of drugs that can be used to treat and prevent a number of conditions associated with menopause.

Available credits: 0.25

Time to complete: 15 minutes


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  • Overview

    An estimated 50 to 70 percent of the more than 64 million postmenopausal women in the US will be affected by genitourinary syndrome of menopause (GSM) symptoms, with dyspareunia and vaginal dryness being the most common. 

    To help clinicians better manage patients living with these bothersome and distressing symptoms, this article will discuss the pathophysiology of dyspareunia and dryness associated with vulvovaginal atrophy (VVA) as well as the mechanisms of action of the various SERMS. It will also cover the indications and usage of the available SERMS in addition to the scientific data regarding the benefits and risks of oral versus topical therapy for the management of dyspareunia and dryness associated with VVA.

  • Disclosure of Conflicts of Interest

    Disclosure of Conflicts of Interest: 

    In accordance with the ACCME Standards for Commercial Support, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. GLC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    David J. Portman, MD
    Founder and Director Emeritus, Columbus Center for Women’s Health Research
    Adjunct Faculty, The Ohio State University
    Department of Obstetrics and Gynecology
    Founder and CEO, Sermonix Pharmaceuticals
    Columbus, OH

    Grant/Research Support: Boehringer Ingelheim, Endoceutics, Palatin Technologies, QuatRx Pharmaceuticals, Shionogi Pharmaceuticals, TherapeuticsMD
    Consultant/Advisory Board: AMAG Pharmaceuticals, Agile Therapeutics, Duchesnay Pharmaceuticals, ITF Pharma
    Commercial Interest Speakers Bureau: AMAG Pharmaceuticals
    Salary and Stockholder: Sermonix Pharmaceuticals

    Reviewers/Content Planners/Authors: 

    • Sean T. Barrett has nothing to disclose.
    • Barry A. Fiedel, PhD has nothing to disclose.
    • Amanda Hilferty has nothing to disclose.
    • Lynne Schneider, PhD has nothing to disclose.
    • Robert Schneider, MSW has nothing to disclose.

  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Describe the pathophysiology underlying dyspareunia and dryness associated with VVA
    • Define the underlying mechanisms of action of the various available SERMS
    • Identify the indications and usage of the available SERMS
    • Cite the scientific data regarding the benefits and risks of oral versus topical therapy for the management of dyspareunia and dryness associated with VVA
  • Target Audience

    This activity is designed to meet the educational needs of the obstetrician and gynecologist, family physician, internal medicine physician, physician assistant, nurse practitioner, and certified nurse midwife.

  • Accreditation and Credit Designation Statements

    Global Learning Collaborative is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Global Learning Collaborative designates this enduring material for a maximum of .25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider(s)/Educational Partner(s)

    Omnia Education is the leading provider of education for women’s health professionals. Our activities are recognized nationwide for providing credible, relevant, and practical information on issues impacting the female patient. Additionally, our unique focus has transformed the CME learning environment, and our ability to help learners recognize and overcome barriers to optimal performance and optimal patient outcomes has positioned us as a leader in women’s health education.

  • Commercial Support

    This activity is supported by an independent educational grant from Duchesnay.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Omnia Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Omnia Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited

    Reproduction of this material is not permitted without written permission from the copyright owner.

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